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What to Know About Japan’s Plan to Release Fukushima Water Into the Ocean_我的网站

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What to Know About Japan’s Plan to Release Fukushima Water Into the Ocean_我的网站

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一 |       随着对雄激素性秃发发病机制认识的不断深入,临床治疗这一毛发疾病的思路也正在不断升级和补充,“局部问题局部治疗”观点在逐渐成型。    

Japan as soon as this week will begin the controversial release of treated water from the Fukushima nuclear power plant into the ocean.
The Japanese government approved the plan two years ago, saying it is necessary to decommission the power plant, which is operated by Tokyo Electric Power Company. Releases will start Thursday “if they encounter no obstacles,” Prime Minister Fumio Kishida announced this week.
“I have asked TEPCO to swiftly prepare for the water discharge in accordance with the plan approved by the Nuclear Regulation Authority, and expect the water release to start on Aug. 24, weather conditions permitting,” Kishida said.
Despite pushback from neighboring nations and fishing groups, Japanese officials said the plan is safe.
What Is the Release Process? 
The wastewater has gone through treatment and is stored in large tanks. Japanese officials say the water needs to be removed so the plant can be decommissioned.
The water will be diluted and released through an underwater tunnel off the coast of Japan. Officials say it will not be near areas where routine fishing occurs.
The entire process is expected to take decades.
Is the Treated Water Safe?
The release plan has been approved by Japan’s nuclear regulation agency and given the go-ahead by the International Atomic Energy Agency, the global nuclear watchdog.
The IAEA’s two-year review of the plan – which involved sampling and testing the treated water – found it to be consistent with the agency’s safety standards with “negligible” impacts to humans and the environment.
“Based on its comprehensive assessment, the IAEA has concluded that the approach and activities to the discharge of ALPS treated water taken by Japan are consistent with relevant international safety standards,” IAEA Director General Rafael Mariano Grossi said in a statement last month.
“Furthermore, the IAEA notes the controlled, gradual discharges of the treated water to the sea, as currently planned and assessed by TEPCO, would have a negligible radiological impact on people and the environment,” he added.
The agency will monitor the water’s release and have a continuous presence on-site at the discharge facility.
“This will ensure the relevant international safety standards continue to be applied throughout the decades-long process laid out by the Government of Japan and TEPCO,” Grossi said.
Nearly all radioactivity has been removed from the treated water – except tritium.
Tritium is a radioactive form of hydrogen that occurs naturally and is also a byproduct of producing electricity at nuclear power plants. It cannot be filtered out of the nuclear wastewater.
Japan plans to dilute the water to bring the level of tritium below regulatory standards. This practice is done at other nuclear power plants, including in the U.S.
One of the biggest critics of the plan is Beijing, a top consumer of exports from Japanese fisheries. Foreign Ministry spokesman Wang Wenbin recently called Japan’s decision “selfish and irresponsible.”
“In disregard of the strong concerns and firm opposition from the international community, the Japanese government announced the decision to start releasing the Fukushima nuclear-contaminated water into the ocean from Aug. 24,” Wang said during a press conference this week, according to a transcription. “This is extremely selfish and irresponsible, as the discharge will spread the risks of nuclear contamination to the rest of the world. And by doing so, Japan is putting its selfish interests above the long-term well being of the entire humanity. China is gravely concerned and strongly opposed to this.”
Hong Kong’s leader this week said the city would "immediately activate" import controls on Japanese seafood to begin on Thursday – the same day as the planned water release.
South Korean activists have also protested the plan, but Seoul recently concluded from its own study that there aren’t any scientific issues.
"Our government has judged that the Japanese side will discharge the contaminated water from the Fukushima nuclear power plant as originally planned and has determined that there are no scientific or technical problems with the planned discharge of the contaminated water," Office for Government Policy Coordination Park First Deputy Park Ku-yeon said this week.
Asked about the situation during a trilateral meeting with President Joe Biden and Prime Minister Kishida at Camp David last week, South Korean President Yoon Suk Yeol answered diplomatically but with obvious concern – assigning the issue the “highest priority” and calling for transparency.
“The Fukushima plant's treated water, if it's going to have some type of impact, it would flow through the entire Pacific Ocean having an impact not just on our three countries but all countries around the world,” Yoon said through a translator. “As such, for the sake of safety and health of the people of our three countries and all members of the international community, that should be something that we need to place the highest priority on. Regarding this treated water, based on scientific principles, all of the processing should be carried out accordingly. And at the same time, internationally recognized and reliable IAEA's investigation results are something that we can trust. And I would like to make sure that everything is conducted and carried out in accordance with the procedures established by the IAEA.”
Japan’s plan has faced strong opposition from local fishing groups.
Kishida met with leaders of the Japanese fishery industry on Monday to pledge long-term support for fishing communities.
But Masanobu Sakamoto, head of the National Federation of Fisheries Cooperatives, said his group remained opposed to the plan, even though some members have gained confidence about its safety.
“Scientific safety and the sense of safety are different,” Sakamoto said. “Even if it’s safe, reputational damage occurs.”
What Was the 2011 Fukushima Disaster?
A magnitude 9.0 earthquake off the coast of Japan triggered a tsunami that hit the Fukushima power plant, triggering meltdowns in three reactors that contaminated the cooling water.
The accident was given the highest rating on the International Nuclear and Radiological Event Scale due to the high radioactive releases from the plant.
。  近日,在上海第二届皮肤健康发展大会暨杨国亮皮肤病学大会暨中国医药教育协会皮肤与健康教育专业委员会学术年会上,有专门从事皮肤毛发类疾病的专家学者发表了明确观点:AGA(即雄激素性秃发)的治疗应从传统治疗转向精准靶向外用治疗。  医学界对雄激素性秃发患者头皮毛囊局部的雄激素代谢与作用机制的认识不断提高,近年来,外用非那雄胺等局部治疗手段进入临床,为雄激素性秃发患者提供了新的治疗选择。

二 |   雄激素性秃发是临床最常见的非瘢痕性脱发类型之一,其典型表现包括发际线后移、头顶部毛发逐渐稀疏以及毛发直径不断变细等。  长期以来,“雄激素性秃发”这一名称容易让公众产生一种直观理解——脱发是否意味着人体内雄激素水平过高?毛发医学专家在会上表示,在临床实际中,多数雄激素性秃发患者的血液睾酮或双氢睾酮水平并没有明显升高。  相关医生介绍,雄激素性秃发的发生至少涉及几个不同层面:一是极少部分患者存在全身雄激素水平异常;二是毛囊局部的睾酮在5α-还原酶作用下转化为双氢睾酮(DHT);三是部分患者的毛囊本身对雄激素更加敏感。

三 |   其中,后两种情况在临床中更为常见。  “毛囊不仅仅是长出头发的结构,它本身具有局部代谢、自我生长和自我调节能力。”现场参会发言的重庆医科大学附属第二医院皮肤科主任医师赵恒光解释说,睾酮可以在毛囊局部经过5α-还原酶转化为活性更强的双氢睾酮,后者持续作用于敏感毛囊后,会推动毛囊逐渐发生“微小化”。  所谓毛囊微小化,是指原本能够生长粗壮终毛的毛囊逐渐缩小,生成的毛发越来越细、越来越短,最终甚至失去正常生发能力。因此,雄激素性秃发并不是突然发生的疾病,而是一个逐步进展的过程。  这一认识也改变着临床治疗的思路。“如果导致毛囊微小化的重要环节主要发生在头皮局部,那么治疗能不能也更靶向头皮局部?”这一问题,正在成为近年来雄激素性秃发治疗方案调整的一个重要方向。  根据大会相关医生分享及现场《中国医学护肤临床洞察2026头皮毛发健康》第17页“常见毛发问题及全周期管理”等资料显示,随着药物递送和制剂技术的发展,非那雄胺不仅有传统口服制剂,更是进一步拓展至外用非那雄胺喷雾剂,其基本治疗逻辑依然是抑制5α-还原酶,减少睾酮向双氢睾酮的转化,但给药方式由全身系统性用药进一步延伸到靶向头皮局部用药。  现场参会医生认为,这一变化并不只是简单的“片剂变喷雾”,背后反映的是皮肤科治疗逐渐走向精准化和局部化的趋势。  由于毛发和头皮位于人体体表,具有天然的局部给药条件。理想的局部治疗,是使药物尽可能在头皮及毛囊周围形成有效作用浓度,同时减少不必要的全身暴露。  专家援引国内外临床研究表示,外用非那雄胺能够降低头皮局部双氢睾酮水平,并改善部分雄激素性秃发患者的毛发生长情况,且对全身激素水平的影响相对较小,这也使一些过去因为担忧系统性不良反应、不能耐受口服治疗,或者具有局部重点治疗需求的患者,多了一种治疗选择。  不过,与会专家同时强调,局部治疗并不意味着传统治疗方式将被简单替代。  目前雄激素性秃发的治疗仍强调个体化管理。

四 | 根据患者年龄、脱发程度、病程、既往治疗效果以及对药物的耐受情况,医生可以在米诺地尔、口服或外用5α-还原酶抑制剂以及其他治疗手段之间进行选择或联合使用。  “不是有了新的治疗方法,过去的方法就失去价值。”赵恒光表示,临床治疗真正关注的,是在疗效和安全性之间找到更好的平衡,并为不同患者提供更多可选择的治疗路径。  现场讲座医生还特别提醒,外用非那雄胺属于经过专门制剂技术设计的药物,并不是将口服非那雄胺片剂碾碎、溶解后就可以自行制成外用药。药物能否稳定溶解、穿透头皮并在毛囊部位形成有效浓度,都涉及特定制剂和药物递送技术,患者不应自行配制使用。

五 |   与此同时,“早识别、早干预、长期管理”仍是雄激素性秃发治疗的重要原则。  由于雄激素对易感毛囊的影响具有持续性,随着病程延长,毛囊可能从粗壮逐渐变细,并最终出现难以逆转的萎缩。因此,专家建议,如果出现发际线明显后移、头顶毛发持续变稀、毛发越来越细等表现,应尽早前往正规医疗机构的皮肤科或毛发专科进行诊断,而不宜仅依靠洗护产品或自行用药长期观察。  从“降低全身雄激素影响”到更加关注“毛囊局部发生了什么”,雄激素性秃发治疗理念的这一变化,也是近年来精准医学在皮肤科领域不断深入的缩影。  专家认为,未来随着毛囊生物学、局部药物递送技术以及长期真实世界研究不断积累,雄激素性秃发治疗可能进一步走向个体化:针对不同发病机制、不同脱发部位和不同患者需求,选择更加精准的治疗方式。  对于患者而言,这种变化的意义或许并不在于出现了某一种“更好的药”,而在于医生手中的治疗工具越来越丰富——在疗效之外,安全性、长期依从性、个体差异和患者需求,正被放在越来越重要的位置。

六 |

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